The Niccoli Lab

Our lab is interested in understanding the molecular mechanisms leading to neuronal cell death in dementia. Dementia's main risk factor is increasing age, and as the population ages the prevalence of this disease has rocketed, making it the leading cause of death in the UK.


We use fruit fly models of dementia to understand disease progression. Fruit flies make excellent models to study this disease as they have well-defined brains, with similar cell types to human brains. They also don't live very long, allowing us to study disease progression throughout the whole lifespan of the organism which is very important in studying diseases affecting older population. 


October 2020: Join us as a Research Fellow

Applications are invited for a Research Fellow to join the Institute of Healthy Ageing (IHA), in the Department of Genetics, Evolution and Environment, in the laboratory of Dr Teresa Niccoli.


The project’s aim is to uncover the molecular mechanisms of neuronal cell death in neurodegeneration by modelling the toxicity linked to CCCCGG hexanucleotide repeat expansion (C9), the most common genetic cause of sporadic and familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The candidate will join an exciting research environment integrating fly research with mouse work. The post-holder will be primarily based in Dr Teresa Niccoli’s laboratory but will be working in close collaboration with Dr Adrian Isaacs at the Dementia Research Institute (DRI).

More info and to apply: HERE

August 2020: Join us at the UCL IHA Virtual Symposium: Neurodegeneration in Flies

This seminar series brings together researchers from around the globe who study neurodegenerative diseases and age-related neurodegeneration using flies. Our sessions will feature world-leading researchers in the field, as well as early-career researchers, sharing their latest findings in neurodegeneration.

More info and to join: HERE

We had fun teaching visitors and curious minds about Dorosophila and how we use them in our research at the Its All Academic UCL Festival on October 4 2019.

At our stall, visitors learned how to differentiate between male and female flies using the microscope and a brush. Visitors also learned about the different wing shapes and the climbing abilities of normal versus sick flies. 

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Niccoli Lab 2019

Designed by Annora Thoeng