The Niccoli Lab

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Our lab is interested in understanding the molecular mechanisms leading to neuronal cell death in dementia. Dementia's main risk factor is increasing age, and as the population ages the prevalence of this disease has rocketed, making it the leading cause of death in the UK.


We use fruit fly models of dementia to understand disease progression. Fruit flies make excellent models to study this disease as they have well-defined brains, with similar cell types to human brains. They also don't live very long, allowing us to study disease progression throughout the whole lifespan of the organism which is very important in studying diseases affecting older population. 


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August 2020: Join us at the UCL IHA Virtual Symposium: Neurodegeneration in Flies

This seminar series brings together researchers from around the globe who study neurodegenerative diseases and age-related neurodegeneration using flies. Our sessions will feature world-leading researchers in the field, as well as early-career researchers, sharing their latest findings in neurodegeneration.

More info and to join: HERE

June 2021: We are looking for a research technician to join our lab!

You will be working on two projects that aim to understand disease mechanisms and test candidate therapeutic targets for frontotemporal dementia, motor neuron disease, and Alzheimer’s disease, using the fruit fly Drosophila melanogaster as the primary model system.

More info: HERE (Closing date June 24)